Cell Physiologist Toxicologist
Leidos is seeking an experienced Research Scientist to perform Inhalation Toxicology Research in support of biomedical research in the Environmental Health Effects Laboratory (EHEL) at the Naval Medical Research Unit Dayton, OH. The successful candidate will serve as Project Lead in cell-based, animal use research studies on environmental and occupational exposures to identify health effects before health and operational performance is compromised in the warfighter. Cell-based studies include the use of in vitro and ex vivo models, bacterial systems and molecular assays to address toxic effects and mechanisms. Research efforts will require assistance with interrogatories, medical and scientific authoring and editing of research proposals, animal use protocols, technical and scientific reports, responses to grants and funding calls; scientific management, coordination of technical review meetings and the preparation and presentation of point papers, technical reports, and other briefings resulting from these meetings, preparation and support of technical summaries and publications resulting from research activities, support in development of Institutional Animal Care and Use Committee (IACUC) protocols for animal research; presentation of research findings at scientific meetings / professional conferences; writing, reviewing, editing, and submitting peer-reviewed articles and technical reports.
Work with a diverse team of scientists, including toxicologists, engineers, neuroscientists, chemists, psychologists, animal behaviorists and biologists, to accomplish the mission of understanding the health effects of operating in military settings.
Design and conduct scientific research on the cellular physiological responses to exposure to chemicals/mixtures, extreme environmental hazards or stressors, to include temperature, humidity, altitude, vibrations, and noise, and/or physical demand.
Design in vitro multicellular tissue models aimed at economically and efficiently screening chemicals and mixtures of military relevance for their potential adverse effects.
Utilize ex vivo and/or in vitro multicellular tissue models to understand subcellular responses/effects and mechanisms of action following exposure.
Correlate/validate ex vivo and/or in vitro multicellular tissue models with animal models of exposure and ultimately translation to humans.
Assist other investigators in the design and execution of research protocols on animal, human and cellular physiology and performance issues of interest to the Navy.
Assist and educate entry level research assistant personnel in the understanding and performance of their duties.
Collect data from cell and tissue models, and animal subjects (as appropriate).
Operate and maintain standard and specialized laboratory equipment.
Perform statistical analyses using SigmaPlot, Statistical Package for the Social Sciences (SPSS) or Statistical Analysis Software (SAS). Examples of the typical analyses required for successful performance include T-tests, Chi-Square, Analyses of Variance, Multivariate Analyses of Variance, analyses of covariance, multivariate analyses of covariance, correlations, linear regressions, multiple linear regressions, and power analyses.
Use multiple computer software packages to create spreadsheets and perform statistical routines.
Prepare technical reports, presentations, and publications.
Independently and proactively prepare mission-relevant proposal applications for toxicological, physiological, psychological, medical, and performance studies.
Develop technical reports, presentations, and publications.
Be willing and able to work nontraditional hours (e.g., nights, weekends) as needed.
Perform other duties as needed.
Ph.D. with 3 years of experience in cellular physiology, or a related scientific field
A minimum of three years’ experience conducting original research, including the design and implementation of protocols with cell and animal models, data analysis, and report production.
Strong background performing mammalian cell culture (to include stem cells, organoids and physiologically relevant tissue models), and aseptic techniques
Strong background in cell physiological research methodology with experience in research methods, design, and statistical analysis in a research setting.
Strong background in cell physiology, cell signaling pathways and translation of models to human physiology and performance.
Proficiency in Microsoft Outlook, Word, PowerPoint, and Excel.
Proficiency in the use of common statistical analysis software, to include SigmaPlot, SPSS and SAS.
Strong technical writing background with experience in writing research proposals, standard operating procedures, animal use protocols for approval by the Institutional Animal Care and Use Committee (human use/Institutional Review Board protocols a plus), technical reports, journal articles, and conference papers.
Experience with various microscopy techniques a plus.
Excellent communication and interpersonal skills and ability to work cooperatively in a team environment.
Self-motivated and capable of working independently and with others.
Ability to obtain Secret Clearance
PhD plus 12 years of relevant experience
Experience in a military or medical research environment is highly desired
Demonstrated experience and success responding to research funding and grant requests for proposals.
The Leidos pay range for this job level is a general guideline only and not a guarantee of compensation or salary. Additional factors considered in extending an offer include (but are not limited to) responsibilities of the job, education, experience, knowledge, skills, and abilities, as well as internal equity, alignment with market data, applicable bargaining agreement (if any), or other law.