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Principal Associate Scientist/Scientist, Clinical Biomarkers, Neuromuscular
About the Role
The Fluid Biomarker group, within the Clinical Sciences is seeking an independent and motivated scientist to join a dynamic team engaged in the discovery and implementation of novel fluid and tissue biomarkers of neuromuscular disease and response to novel therapeutics. This predominantly laboratory-based position will utilize state-of-the-art approaches to identify, qualify and utilize mainly immunological-based measures to monitor disease progression, target engagement and pharmacodynamic responses indicative of biological changes in clinical study samples. Responsibilities include identification, evaluation, characterization, and development of relevant fluid and tissue biomarkers in support of programs across Biogen’s neuromuscular indication portfolio, but also indications related to neurodegeneration and psychiatric disorders.
What You’ll Do
Identify and implement immuno-based platforms (e.g. ELISAs, ELLA, SIMOA, MSD U-plex/S-plex) to develop and qualify fit-for-purpose biomarker assays for clinical sample assessment of neuromuscular disorder-related analytes
Modify existing and/or develop novel assays for the assessment of biological analytes utilizing biochemical (immuno-assays, western blotting, competitive mAb binding) and potentially molecular approaches in preclinical and human samples
Engage CROs for the transfer and/or development of assays for external fit-for-purpose qualification and clinical sample analysis
Engage both internal research colleagues as well as external research collaborations to support identification of novel biomarkers
Accurate and complete documentation of methods and results in an electronic notebook environment and in qualification and study reports for regulatory submission
Review internal and/or external clinical sample analysis data for acceptable quality control criteria
Who You Are
You will enjoy working in the laboratory to develop and implement novel measures of biological analytes in clinical samples contributing to the understanding human disease mechanisms and identifying changes in those processes’ indicative of pharmacological manipulation.
Doctorate with biological sciences or Neuroscience with 2+ years of clinical assay development experience; Master’s degree with 4+ years of clinical assay development experience in industry; Bachelors with 6+ years of clinical assay development experience in industry.
Experience in the development and qualification of fluid biomarker assays in the preclinical and clinical setting
Proven experience with high-sensitivity immunoassay platforms, including novel assay development, troubleshooting and implementation
Experience in interpreting biological or pharmacodynamic measures indicative of disease progression and/or pharmacological manipulation
Ability to quickly absorb new information and develop an understanding of the relevant biology, pathway, mechanism of action and multiple sclerosis disease indication in general
Flexible, results oriented, independent self-starter with effective communication skills who enjoys working in a dynamic environment
Specific background knowledge of neuromuscular biomarkers and disease pathways
Additional background in neurodegenerative and psychiatric disorders
Our mission to find therapies for neurological and rare diseases is a unique focus within our industry and this shared purpose is what connects us as a team. We work together to overcome obstacles and to follow the science. We are resilient as we strive to make an impact on our patients’ lives and on changing the course of medicine. Together, we pioneer. Together, we thrive.
All your information will be kept confidential according to EEO guidelines.