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Job Details

Pfizer: One of the World's Premier Biopharmaceutical Companies

Principal Scientist, Vaccines (4845293_Pearl_River)




Full Time


Pearl River, New York, United States


The candidate will be an experienced lab-based research scientist with in-depth knowledge of virology and antiviral drug discovery/development, disease mechanisms, and host immune responses. The candidate will have specific experience in SARS-CoV-2 virus culture and assays. A proven track record of peer reviewed publications and experience in verbal presentation are essential. In addition to high technical competence, the incumbent understands and will articulate program objectives, experimental results, propose working hypothesis, and provide technical guidance for future assignments to address a problem or evaluate a process/procedure. The candidate will work in proximity with project teams, supporting lines and team members to drive experimental design and logistics, demonstrating leadership skills. An ability to collaborate within cross-functional and across multidisciplinary teams is essential. The candidate will be expected to share and present research results in program meetings and to author appropriate documents (reports, standard operation procedures, regulatory documents and publications).


  • Work independently in a team to propose, plan and execute experiments, trouble-shoot, analyze, document results, and to ensure high data quality.
  • Establish and/or optimize assays, and carry out experiments to test antiviral activity, mechanism of action, as well as virus drug resistance and virus fitness characterization.
  • Work in BSL2 and BSL3 labs on antiviral assays required
  • Work as a team member in proposing working hypothesis, identify and validate novel drug targets, develop and validate a variety of cell-based and functional assays, and be actively involved in data interpretation.
  • Present results in internal meetings, scientific conferences, and author study reports and publications.
  • Being up-to-date and understanding relevant work published by the scientific community and using the information to improve internal processes and/or establish new procedures/technologies.


  • PhD in Virology, Molecular biology, Immunology or a related field with >5 years of experience, preferably in a pharmaceutical or biotechnology environment, or relevant academic experiences in small molecule drug discovery and R&D using state-of-the-art technologies.
  • Self-motivated and able to work effectively as part of a cross-functional team.
  • Proven delivery of objectives in a complex matrix environment.
  • Skills in cell and virus culture, recombinant technology, ELISA, immunofluorescence, flow cytometry, luciferase assay, qPCR, imaging-based assays are a must.
  • Generate and deliver robust data packages under tight timelines.
  • Excellent verbal and written communication skills are required.
  • Ability to write protocols, reports and publications in peer-reviewed journals required.
  • Design new approaches to improve existing technologies and providing proposals to solve challenging tasks.
  • Proficiency with Excel, PowerPoint, Word, DNA sequence analysis software, and statistical software including GraphPad Prism is essential.
  • Experience in preclinical in vivo antiviral pharmacology animal studies
  • Viral pathogenesis and immunology experience
  • Virology experience in SARS-CoV-2 or other coronaviruses, as well as RNA viruses such as influenza or RSV
  • Prior experience in antiviral drug resistance
  • Expertise with drug combination studies


  • Ability to perform large number of assays in 96- and 384-well plates and compile the data appropriately
  • Ability to perform statistical analysis of experiments
  • Ability to search and interpret the scientific literature and translate it to the own required experiments
  • Ability to sit for a longer time at a Biosafety cabinet.


  • The current location for the candidate will be in Pearl River NY. The ability to travel to internal and external collaboration partners is required. Dependent on milestones, experiments, availability of equipment, such as robots, work on bank holidays and weekends might be necessary on occasion.
  • Occasionally travel to other Pfizer sites, selected vendors and national/international conferences.


Eligible for Relocation Package

Eligible for Employee Referral Bonus

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development