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Principal Scientist, In Vivo Pharmacology (CVM) (344267BR)
Job Description $9.0 billion R&D spend to develop breakthrough medicines! We are seeking a highly motivated scientist to join our In Vivo Pharmacology team in the Cardiovascular and Metabolism (CVM) Disease Area at the Novartis Institutes for BioMedical Research (NIBR) located in Cambridge, MA. Cardiovascular disease is the leading cause of death worldwide, taking an estimated 17.9 million lives each year. Our team is dedicated to the creation and development of innovative medicines to change this alarming statistic. We conceive, develop, validate and employ pharmacological tools to evaluate the efficacy and safety of novel cardiovascular drug candidates.
As an In Vivo Pharmacologist, you will work independently and collaboratively in an inter-disciplinary setting to design and execute experiments in preclinical models, analyze/interpret data, write study reports and give oral presentations. You will drive drug discovery for therapies targeting atherosclerosis, while also having the opportunity to broaden your knowledge of other therapeutic areas within CVM (e.g. heart failure, arrhythmia, and metabolism).
• Establish in vivo and ex vivo models of atherosclerosis progression and/or regression
• Establish in vivo and ex vivo tools (e.g. methods to determine macrophage phenotype, function and trafficking) required to define the impact of potential therapeutics on plaque composition and function
• Design, execute, analyze and document in vivo and ex vivo experiments
• Perform biochemical and/or histological analyses on samples
• Identify targets to pursue in collaboration with colleagues, and progress targets forward toward therapeutics
• With time and experience, lead one or more drug development projects in the field of atherosclerosis from target concept to IND-enabling studies
• Recognize and leverage external collaboration opportunities that amplify the department’s research
• Present results in lab, team and department meetings
• Independently compose research reports to support regulatory filings