Chemoproteomics Sci. Mass spectrometry instrumentation & automation (345085BR)
85% of the proteome is currently undrugged. Join our effort to tackle a longstanding challenge in early drug discovery by identifying covalent small molecules that modulate the activity of these so far undrugged targets and pathways to positively impact human health.
The Chemical Biology and Therapeutics department is seeking a highly motivated and adaptable candidate for a Scientist position to expand its current effort in chemical proteomics and covalent drug discovery.
Experience with protein/peptide analysis and excellent quantitative analytical skills using quantitative mass spectrometry methods (e.g. TMT, label-free) are required in addition to familiarity with latest chemical proteomics methodology, mass spectrometry equipment, and approaches.
The successful candidate will have demonstrated abilities in application and development of high-throughput proteomics and quantitative mass spectrometry.
The position requires the ability to independently design quantitative (chemo)proteomics experiments, operate and troubleshoot automation and data acquisition equipment as well as optimize existing workflows.
Effective self-management is required for success in a highly dynamic team environment with sometimes rapidly changing objectives.
Applicants require good organizational and communication skills together with the ability to interpret and present results and scientific information critically and objectively.
Primary responsibilities include:
• Execution and automation of proteomic sample preparation workflows
• Operation, maintenance, and troubleshooting of state-of-the art mass spectrometry and associated equipment
• Analysis of quantitative MS data using equipment vendor and 3rd party software
• Report generation and presentation of results and interpretations