Scientific Director, Systems Neuroscience (R1558655-en-us)
At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.
Position: Scientific Director, Systems Neuroscience
Hiring Manager: Vice President Neuroscience Translation and Strategy • Neuroscience TRC
Location: Kendall Square, MA, USA (anticipated to move to East Cambridge in 2023)
The Neuroscience TRC is committed to development of transformational therapeutics for patients with neurodegenerative and neuromuscular diseases. We have built a network of external partnerships across multiple treatment modalities (small molecules, biologics and RNA targeting) that leverage our leadership in protein homeostasis and inflammation to attack neurological diseases. Internal research focuses on protein homeostasis by direct and ligand directed degradation, neuroinflammation and remyelination.
Areas of interest include, but are not limited to, the following approaches:
Disease modifying therapies for neurodegenerative, neuro-inflammatory and neuromuscular diseases; CNS targets that modulate protein homeostasis, protein clearance, inflammation and reduce or eliminate toxic protein production; Emerging technologies (RNA, DNA targeting, gene regulation, editing and replacement, vector optimization) that when matched to underlying disease genetics can deliver a precision medicine portfolio with a high probability of success to address unmet medical needs; Targets in orphan/rare neurological and neuromuscular diseases. AI/ML in target identification and neurology drug discovery; Translational tools and technologies such as neuroimaging and fluid biomarkers to track neurodegenerative disease; Novel blood brain-barrier delivery technologies.
The Neuroscience Thematic Research Center (TRC) works via an “externalized portfolio” model; projects are driven by TRC strategy based on data generated predominantly in collaboration with external partners. The Director, Systems Neuroscience will
Work closely with the team to move programs accurately and timely from the laboratory to clinical studies.
Be responsible for a range of translational initiatives across multiple projects using diverse platforms that cover the breadth of therapeutic indications across our portfolio in neurodegenerative disorders.
Help map and refine disease area landscaping based on intersection of unmet clinical needs and evolving asset profiles.
On request, work with Business Development to source, review and critique business development opportunities.
Work in close collaboration with highly visible external partners (start-ups, academics, Foundations, contract research organizations (CRO), other Pharma) in addition to internal stakeholders (Neuroscience TRC scientists, Informatics & Predictive Sciences, biology, imaging, epidemiology, genetics, translational development, clinical development, statistics, and regulatory teams).
Help identify, contract with and ensure quality oversight of CRO-based translational activities aligned with the NeuroTRC strategy.
May be assigned responsibility for leading BMS participation in select disease consortia and maintaining key external expert relationships.
Minimum Education Required: PhD in Neuroscience and/or MD/PhD with specialty training in Neurology
8+ years of relevant industry / academic experience, with at least 3 years focused specifically in target identification and validation
Deep understanding of the pathophysiology underlying the neurodegenerative disorders within our portfolio (including but not limited to Alzheimer disease, Multiple Sclerosis, Amyotrophic Lateral Sclerosis, Multiple System Atrophy, Huntington Disease, Parkinson Disease) and familiarity with constructing translatable proof of concept studies.
Strong facility with data analytic approaches and data interpretation in the context of studies and the competitive landscape.
Reputation for constructive productive heavily matrixed work style.
Desired Experience and Characteristics:
First-hand experience with the nuances of target prioritization and validation and construction of compelling preclinical Proof of Concept packages.
Track record of designing hypothesis driven preclinical programs and driving delivery of well-written summaries (manuscripts, presentations, white papers, etc.) and relevant sections of regulatory documents (e.g., clinical study protocols, informed consent forms and study reports)
Experience in constructing contracts and directly overseeing contractual obligations with external partners ranging from academics to vendors
Demonstrated ability to develop and maintain external collaborations influencing performance to the highest level of productivity
Ability to work as a member of multidisciplinary drug development teams with demonstrated problem-solving skills and the flexibility to succeed in a dynamic and changing environment
Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.
To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.
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