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Senior Scientist, Cell Therapy (R-140731_Gaithersburg)





Gaithersburg, Maryland, United States

Senior Scientist, Cell Therapy

Do you have a passion for Science? Would you like to apply your expertise to impact a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.

About AstraZeneca in Gaithersburg, MD:

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you’ll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams.

Summary of the group:

The Cell Culture and Fermentation Sciences Group is accountable for cell line development, process development, and process characterization. This group assists in the scale up and technical transfer of processes to different clinical and commercial sites and also supports manufacturing deviations and regulatory submissions as needed.

Main Duties & Responsibilities:

  • Work with research team to understand and design vector sequences for lentiviral vector manufacturing.
  • Design and develop lentiviral vectors for autologous CAR-T therapies.
  • Develop the tools to enable understanding of optimal lentiviral vector needed for clinical and commercial applications.
  • Molecular engineering of modular genetic switches and protein expression control elements
  • Develop/evaluate LVV packaging and producer cell lines
  • Development of lenti vector production including adherent and suspension production
  • As needed, designs and develops optimal manufacturing process solutions required to enable effective delivery of gene therapy products for CAR-T projects. The candidate will ensure scientifically sound design and scalable processes are developed and properly executed.
  • Designs and conducts laboratory projects/experiments, develop methods, generate interpret and report scientific data.
    • Competent in trouble shooting and theory;
    • Oversight of outsource vendor contracts for vector production;
    • Support lentiviral vector manufacturing by tech transfer and help in trouble shoot;
  • Present experimental results at internal and external meetings; author and contribute to scientific publications, patents, and regulatory submissions;
  • Work effectively and collaboratively as a team member within a highly matrixed organizational structure;

Education & Experience Requirements:

Education: PhD and 0+ years, or MS and 8 + years BS and 10+ years of relevant experience.

Required Skills:

  • Has a good understanding and application of procedures relating to gene therapy and molecular biology.
  • Extensive experience with molecular biology relevant to lentivirus design, experience with developing packaging and producer cell lines, vector bioproduction, including optimizing cell growth kinetics, scale-up, growth factors and feed strategy
  • Understanding of product design and commercial application of cell and gene modification modalities

Desired Skills:

  • Biotechnology or pharmaceutical industry experience working in GMP environment and FDA-regulated industry
  • Process development, QbD, and risk-based development using statistics and programs such as jmp
  • Experience with CAR-T process development;
  • T cell culture and engineering;
  • Flow cytometry;

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.

So, what’s next!

Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it’s yours.

Where can I find out more?

Check out our landing page for more information on our BPD group [Register to View]

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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.