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Principal Scientist - AAV Process Development, Upstream (347677BR)





San Diego, California, United States

Job Description Over 900+ clinical trials validate that gene therapies are transforming the practice of medicine. You will have an opportunity to join the NIBR Biologics Center (NBC) and be at the cutting edge, leading the development of innovative medicines that can improve lives of patients.

NBC builds the biologics pipeline in collaboration with NIBR Disease Areas and Platforms via a breadth of technologies for discovery of antibody, protein and gene therapy-based therapeutics.

The Biotherapeutic Engineering and Gene Therapy (BEGT) group within NBC drives a diverse portfolio of modalities including therapeutic proteins, multi-specific antibodies, CAR-T, RNA therapeutics and rAAV. Through cell and viral engineering as well as innovative and rational protein design, the BEGT group is a global team that works collaboratively with disease area groups to broaden the use of biologics into therapeutic applications where conventional antibodies have limitations.

This role is responsible for executing early-stage process development with the focus on developability for early-stage AAV gene therapy pipeline portfolio as well as new platform process for existing and novel AAV capsids and cargo vectors.

What you'll be doing:

• Lead efforts to develop innovative and more cost-effective next generation AAV manufacturing platform.
• Design and execute experiments to drive innovative technology and platform evaluation for next generation capsids and cargo vectors.
• Lead and provide SME support collaboratively in operational and strategic discussion within a global team.
• Serve as an interface between Cell Line Development and upstream production team in support of developing and optimizing next generation AAV pre- packaging /packaging and producer cell lines.
• Serve as a SME to transfer knowledge and work collaboratively with Technical Research & Development team to advance pipeline programs into clinical phases.
• Provide technical support, training, and SME knowledge to assist with the development of junior staff.
• Manage multiple project workflow to ensure timely delivery.
• Prepare protocols, reports and provide high quality data and electronic notebook documentation.
• Other related duties as assigned.