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Job Details


Bristol-Meyers Squibb, Co.

Scientific Director - DMPK

Pharmaceuticals

All

Yearly

No

Cambridge, Massachusetts, United States

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

When you join BMS, you are joining a diverse, high-achieving team united by a common mission.

Nonclinical Research and Development (NCRD) is an integrated function with responsibility for characterizing nonclinical safety and disposition characteristics of the entire BMS Research and Development pipeline programs, with critical role from early discovery to submission of marketing authorization applications. We utilize our deep expertise in toxicology/pathology, ADME, PK/PD, biopharmaceutics and Bioanalytics in all modalities (small and large molecules, cellular therapies and other novel modalities) to collaborate with peer R&D functions to identify and solve issues, discover high quality drug candidates, enable their clinical development and successful marketing authorizations across the globe.


Here, you’ll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You’ll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.

Position Summary:

We are seeking a passionate and experienced research scientist to join our Drug Metabolism and Pharmacokinetic (DMPK) Group as a Director. The role is in the Pharmaceutical Candidate Optimization (PCO) department within NCRD and encompasses broad support for Discovery programs and has a diverse range of expertise in DMPK, toxicology, pharmaceutics and bioanalytical sciences.

In this role, the selected candidate will provide deep scientific expertise and strong strategic leadership on DMPK and pharmacokinetic-pharmacodynamic (PK-PD) modeling in support of small molecule and biologic Discovery projects. He or she will be expected to lead a team of scientists to devise strategies and implement experiments to understand drug disposition mechanisms and PK-PD relationships for issue resolution, program advancement and translation of dosage regimens from preclinical to clinical. The individual will work closely with therapeutic area heads to influence drug discovery in Immunology, Cardiovascular, Fibrosis and/or Oncology with strong mentorship within the department and across the Discovery portfolio.

Essential Job Responsibilities:

  • Design and execute preclinical in vitro and in vivo studies to understand the PK and absorption, metabolism, distribution, and excretion (ADME) of drug candidates

  • Provide expertise in human PK and efficacious dose prediction of drug candidates using mechanistically sound approaches

  • Experience in PK and PK/PD data analysis and modeling/simulation and ability to leverage in vitro and in vivo data as well as competitor clinical information to guide translation biomarker strategies and predict drug/drug interaction potential

  • Responsible for overseeing the analysis, interpretation, integration and reporting of preclinical DMPK data within team

Basic Qualifications:

  • Bachelor's Degree and 15+ years of academic / industry experience

or

  • Master's Degree and 12+ years of academic / industry experience

​or

  • PhD and 8+ years of academic / industry experience

​Plus 6+ years of leadership experience

Preferred Qualifications:

  • Ph.D. in pharmacokinetics, drug metabolism or related discipline with a minimum of 12 years of relevant industrial experience

  • A deep understanding of DMPK and PK-PD principles and hands-on experience in these areas are essential to this job

  • Demonstrated problem-solving skills, critical thinking ability on hypothesis generation, and capability of integrating data using modeling and simulation are required

  • Ability to plan, organize, mentor, and critically assess and/or perform PK/PD data analyses/modeling

  • Knowledge of the latest in technological and regulatory advances in the DMPK arena and demonstrate strong interest and expertise in PK and physicochemical properties modeling techniques

  • Prior managerial experience is a plus

  • Excellent communication skills and the ability to lead and collaborate in a multi-discipline team setting are required for this role

#LI-Hybrid

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to . Visit[Register to View] target="_blank"> [Register to View] to access our complete Equal Employment Opportunity statement.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.