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Job Details


Novartis

Sr Scientist Protein Modeler Genome Editor Discovery Novartis NIBR

Pharmaceuticals

All

Full Time

On Site

No

San Diego, California, United States

Job Description

4 FDA approved drugs; 15+ clinical candidates; 400+ patents; 21 years of NIBR San Diego - John Jay history!

The Genome Editor Discovery Group – a key component of the NIBR San Diego Genome Engineering Platform - is recruiting a Senior Scientist to join a highly collaborative global effort devoted to discovering the next generation of transformational genome-targeting medicines. The San Diego Genome Engineering Platform comprises a core team of +20 scientists with additional access to a wide repertoire of world-class collaborative functions including automation, protein expression, protein engineering, molecular biology, data science, pharmacology, and drug discovery. The San Diego Genome Engineering Platform itself forms part of a larger genome engineering effort comprising +40 scientists globally, which individually or collectively interact with project teams to tailor targeted genome engineering treatments for the most urgent unmet medical needs. The successful candidate will join a team devoted to discovering, engineering, and tailoring novel genome modifying effectors ideally suited to achieving favorable on- and off-target effector profiles for key therapeutic indications, working with the larger team to profile and characterize effector candidates for their therapeutic potential. While significant wetlab expertise is a must and a feature of the role, the successful candidate is bring to these challenging problems the approaches of computational and structural biology, including significant protein and nucleotide sequence analysis, predictive models including some familiarity with the use of methods rooted in artificial intelligence approaches, and enzymology.

Your responsibilities include:

• Contributing to the conception of one or more strategies for the discovery and/or development of novel genome modifying effectors with tailored therapeutic potential, where effectors can comprise nucleases and their derivatives, editors, writers, readers, transcriptases, combinations of multiple such effectors, or classes of effectors as yet undefined
• Executing, either alone or with others, aspects of this strategy as defined by the team and from the bench
• Modeling changes to key proteins to include sequence substitution, domain shuffling, active-site changes, creation of fusion proteins, and other approaches aimed at generating and testing novel genome modifiers
• Converting models to testable constructs via molecular biology approaches
• Modeling and/or testing large numbers of potential variants
• Communicating effectively with diverse project teams and other core groups across NIBR to coordinate with molecular biology, structural biology, computational modeling, disease area, and automation experts