Senior Scientist, Oncology Bioinformatics
The Oncology Genomics and Analytics (OGA) team is seeking a passionate and creative computational biologist to help discover the next wave of cancer therapies. Oncology research at our company is driven by a deep interest in the intrinsic biology of cancer cells as well as the complex intercellular interactions in the tumor microenvironment, and how diverse points of intervention can be combined to achieve ever-higher rates of durable response and patient survival. You will collaborate closely with colleagues in Discovery Research and will be based at our Research Lab in Boston, MA.
In this exciting role, you will:
Contribute to multiple stages of drug discovery by interrogating multi-omics molecular profiling datasets including large-scale single-cell and spatially-resolved molecular profiling datasets as well as functional genomics screens.
Collaborate with experimental scientists to characterize novel targets coming from genetics, translational and disease pathway exploration, explore target engagement, research mechanisms of action, and provide functional validation of novel drug targets.
Be proactive and work collaboratively with various project teams across scientific disciplines and functions, bringing together genetics, pharmacology, chemistry and molecular biology.
Contribute to iterative experimental design and mechanistic hypotheses generation through the mining and interpretation of complex biological data.
Engage with Discovery teams to translate biological hypotheses into computational interrogations of multi-omics molecular profiles
Lead efforts on the experimental design, analysis and interpretation of DNA and RNA sequencing experiments in support of discovery research programs
Identify, analyze and integrate internal and external data and knowledge resources to enable data mining in a biological context to inform target validation and mechanism of action
Work with in-house, open-source and/or commercially available software platforms for the processing and analysis of DNA and RNA data
Assist with project management by coordinating efforts with internal and external collaborators
Survey the literature on novel bioinformatics analysis methodology and algorithms, and introduce them in-house when appropriate
Education Minimum Requirement:
Ph.D. in Bioinformatics, Biostatistics, Computational Biology, Computer Science, Genetics, Immunology, Mathematics, Molecular Biology, Statistics or related field
Required Experience and Skills:
Demonstrated experience on the computational analysis and interpretation of large-scale DNA and/or RNA sequencing datasets
Familiarity with public databases and repositories of bulk and single-cell DNA and RNA profiling data
Proficiency in statistical computing environments and programming languages, such as R or Python
Excellent attention to detail and strong communication (oral and written) skills
Self-motivated and capable of prioritizing deliverables among multiple simultaneous projects
Builds strong relationships within highly collaborative, multidisciplinary teams
Preferred Experience and Skills:
Knowledge of immunology or cancer biology
Knowledge of experimental design and statistical hypothesis testing
Familiarity with the analysis of data derived from functional genomics screens
Capable of integrating information generated from multiple sources to strengthen research hypotheses
Experience with high-performance Linux cluster and cloud computing
Previous experience with machine learning or statistical inference techniques is a plus
Strong publication record
We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.
Who we are …
We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.
What we look for …
In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.
Invent. Impact. Inspire.
NOTICE FOR INTERNAL APPLICANTS
In accordance with [Register to View] all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.
If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.
Current Employees apply [Register to View]
Current Contingent Workers apply [Register to View]
US and Puerto Rico Residents Only:
Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please [Register to View] if you need an accommodation during the application or hiring process.
For more information about personal rights under Equal Employment Opportunity, visit:
We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.
Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
Flexible Work Arrangements:
Valid Driving License:
Number of Openings:1