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Job Details

Merck & Co. Inc.

Senior Scientist, Early Discovery Genetics- Human Genetic Validation



Full Time

On Site


Boston, Massachusetts, United States

Job Description

The company's Early Discovery Genetics Human Genetic Validation (EDG-HGV) team within the Department of Genome and Biomarker Sciences (GBS) works with multiple therapeutic areas (Cardiometabolic, Ophthalmology, Immunology and Neuroscience) to identify and validate new targets based on Human Genetics. Our mission is to identify and validate human genetic targets and to develop and apply improved human model systems to better understand each target’s mechanism of action. Our group utilizes genetic (CRISPR and siRNA) and pharmacological manipulations of human induced pluripotent stem cell (iPSC) model systems to validate the role of targets in mechanisms related to pathobiology of human diseases.

The company's EDG-HGV group is seeking a passionate and dedicated experimental biologist to join our team as a Senior Scientist. The Senior Scientist will create innovative spheroid and organoid models from healthy and diseased human iPSC lines and establish functional assays to validate human genetic targets. In close collaboration with GBS and therapeutic area colleagues, the successful candidate will develop robust and scalable organoid protocols, implement genome editing and multi-omics methods to evaluate organoids, and develop imaging-based protocols for studying pharmacological responses with diseased organoids. You will be part of a dynamic and challenging early discovery research environment that is based at our Research Labs in Boston, MA. In this role, you will develop in-vitro stable and iPSC-derived organoid models for different human diseases. The Senior Scientist will report into the HGV team lead within EDG and will be expected to work both independently and collaboratively with colleagues.

The responsibilities of this Senior Scientist role include but are not limited to:

  • Formulate and execute on validating studies of Human Genetic targets anchored in collaboration with experimental scientists within and outside GBS.

  • Work with cross-functional teams including bioinformaticians, disease area biologists, pharmacologists and chemists for execution of the Genetics targets across early discovery pipeline.

  • Effectively communicate and present data to diverse group of scientists including senior managers.



  • MS with 8+ years of experience or PhD with 2+ years of experience in molecular/cellular biology or related biological fields

  • Demonstrate significant research accomplishment with proven publication record

  • Possess excellent communication skills with ability to clear present scientific data and project update to diverse group of scientists including senior management

  • Experience in working in collaborative environment to advance scientific projects.


  • Experience with human stem cell and organoid culture, genetic/genomic manipulations (CRISPR/siRNA), and confocal/fluorescent imaging approaches are needed.

  • Previous experience working in drug discovery projects

  • Experience in the field of Neuro/Psychiatric, Cardiometabolism or Immunology.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization.


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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

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Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

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Requisition ID:R130167