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Job Details

Merck & Co. Inc.

Senior Scientist, Oncology Target Discovery



Full Time

On Site


Boston, Massachusetts, United States

Job Description

We are seeking a highly qualified and motivated scientist with a strong background in Oncology target identification and validation to join a cross-functional team within Discovery Oncology. The successful candidate will have a track record of innovative and collaborative research demonstrated through peer-reviewed publications. Primary responsibilities will include designing and executing experiments in the laboratory to identify and validate novel targets, focusing on scientific areas where we have asymmetric advantages to deliver novel targets into the early discovery pipeline. The Senior Scientist will operate in a highly collaborative and matrixed environment, and an ability to communicate clearly and collaborate effectively with colleagues from different disciplines will be essential.

In this exciting role, you will:

  • Design, conduct, interpret, and communicate experiments to identify and validate novel targets in Oncology

  • Develop new methods using CRISPR technology to enable the broad use of genetic screening and validation

  • Monitor, review, and critically interpret published work to guide internal research, particularly pertaining to new methods for genetic perturbation

  • Collaborate with colleagues in cross-functional teams from Discovery Oncology, in vivo Pharmacology, Genome and Biomarker Sciences, Chemical Biology, and Quantitative Biosciences to develop and integrate enabling technology to identify and validate novel targets

Required Experience and Skills:

  • Ph.D. in cell and molecular biology or related field

  • Background in cancer biology

  • Demonstrated expertise in functional genomics

  • Expertise in standard molecular biology techniques including PCR, qRT-PCR, and western blotting

  • Expertise in multiple methods of genetic perturbation (siRNA, shRNA, CRISPR using lentivirus and RNPs, inducible systems)

  • Experience with model and assay development

  • Experience with cloning and lentivirus generation; overexpression of wildtype and mutant constructs

  • Experience with assessment of CRISPR editing efficiency using Sanger sequencing or Next Generation Sequencing (NGS)

  • Demonstrated ability to work independently to design experiments, interpret data, troubleshoot, and suggest next steps

  • Candidate should be a strong team player with excellent oral and written communication skills and with a demonstrated ability to work collaboratively and thrive in a team environment

  • Proven record of innovative thinking to propose and champion new ideas and solve problems

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth


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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

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Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

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Requisition ID:R127631