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Job Details

Merck & Co. Inc.

Senior Scientist – Chemical Biology Chemistry





Kenilworth, New Jersey, United States

Job Description

Become a part of the cutting edge and highly innovative Chemical Biology and Discovery Chemistry departments. Using robust scientific methodology, bleeding edge chemistry, and state-of-the-art instrumentation and automation, we collaborate to discover the next medical breakthrough. To achieve our goal, we focus on delivering novel mechanisms into our pipeline, expanding druggable space, and the pursuit of detailed knowledge of the mechanism of action for our key pipeline assets. We partner with multiple functional groups to complement capabilities, accelerate discoveries, and advance the best drug candidates into the clinic for significant unmet medical needs.

Passion for thinking outside the box is critical in Chemical Biology as a field and to the success of enabling drug discovery programs. We are therefore seeking a highly motivated Senior Scientist to join the Chemical Biology group in the Discovery Chemistry organization within our company’s Research Laboratories.

The successful candidate will work closely with scientists in Chemical Biology (comprising chemistry, proteomics, and cell pharmacology) as well as colleagues in Discovery Chemistry, Quantitative Biosciences, Genetics and Biomarker Sciences, and Therapeutic Area Biology.

  • Become part of a creative and flexible team; collaborate and work closely with other scientists.

  • Contribute to project strategy, experimental design, execution, analysis, and interpretation of experiments.

  • Collaborate with Oncology, Immunology, Cardiovascular and Metabolic Diseases, Neuroscience and Infectious Diseases discovery teams to develop and execute on Chemical Biology partnered programs.

  • Contribute to the development of technology builds that further enable the Chemical Biology vision and mission.

  • Establish strong relationships within highly collaborative, multidisciplinary teams to effectively drive drug discovery initiatives.

  • Function and communicate effectively in a highly productive multi-disciplinary environment.

Preferred Experience and Skills:

  • Independent synthetic chemistry

  • Hands-on exposure to cell culture and experimental pharmacology

  • Have a good understanding of biology concepts and chemical application to solve biological problems

  • Experience in one or more of the following:

    • Mechanistic studies of drug action or drug target ID

    • Novel chemical probe development

    • Targeted protein degradation

    • CRISPR genome editing

    • Live cell imaging or other novel cellular assays

    • Drugging/targeting RNA with small molecules

Required Experience:

  • PhD or equivalent in Chemical Biology or a related discipline (MS W/3+ yrs, BS w/5+ yrs working experience in a pharma, biotech or academic setting)

  • A track record of achievement in independently designing and executing experiments is required

  • Highly self-motivated, creative, and critical thinking to solve complex technical and scientific problems with excellent attention to detail

  • Strong organizational and communication (oral and written) skills

  • Robust publication record

  • Possess exemplary analytical skills

  • Ability to work independently yet team-oriented and able to build strong relationships in highly collaborative, multidisciplinary teams to effectively drive early drug discovery initiatives

  • Capable of prioritizing deliverables among multiple simultaneous projects

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization.


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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

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Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

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Requisition ID:R130363