PET kinetic modeler (R132453)
Our company is currently seeking a qualified PET modeler within the Department of Translational Medicine located at our West Point, PA site in suburban Philadelphia. This innovative team consists of chemists, imaging physiologists, PET modelers and other biological and computational scientists. The group currently has state-of-the-art PET radiochemistry facilities and imaging instrumentation (PET, SPECT, CT, MRI, and optical) for in vivo imaging in preclinical species.
The successful candidate will be responsible for developing and applying kinetic modeling strategies to analyze and interpret preclinical and clinical PET imaging data. In addition, the successful candidate will be able to develop appropriate solutions to overcome challenges associated with the discovery of novel radiotracers and applications of established PET tracers.
Duties would include:
Collaborate with therapeutic area teams to identify, implement, and interpret PET imaging solutions to help drive drug discovery programs.
Responsibility for the kinetic modeling and parameter estimation of PET and SPECT data from preclinical and clinical imaging studies including, including practical interpretation of the results.
Contribution to PET study design.
Contribution to imaging protocols in regulatory documents required for clinical PET studies.
Presentation of research results and writing of manuscripts for submission to peer-reviewed journals.
Desired Skills and Experience
Ph.D. in biomedical engineering or a discipline relevant to PET tracer kinetic modeling with a minimum of 8 years of experience in industry or academia, M.S. in biomedical engineering or related field with a minimum of 12 years of experience in the pharmaceutical industry.
Expertise in quantitative kinetic modeling of CNS PET data and interpretation of kinetic modeling results.
Experience processing PET Image data, including image registration and applying tissue compartment models.
An ability to develop appropriate solutions to overcome challenges associated with PET tracer kinetic modeling
A published record of successful research.
Strong written and oral communication skills.
Interpersonal skills necessary for working in a highly collaborative, cross-functional working environment.
Flexibility and the ability to adapt to a fast-paced research environment.
Ability to work independently.
Preferred experience and skills:
Experience with study design oriented to characterize selectivity, specific signal, tissue/plasma kinetics of novel PET tracers.
Practical experience with MATLAB as a programming tool for image analysis and PMOD applications
Experience with multiple image formats (e.g. nifti, dicom, ecat, etc.).
We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.
Who we are …
We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.
What we look for …
In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization.
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