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Job Details

Merck & Co. Inc.

Scientist, Antibody Discovery (R133043)





Boston, Massachusetts, United States

Job Description

We are looking for a skilled bench scientist with technical background antibody discovery to join our In Vitro Display Group in Discovery Biologics, Protein Sciences in Boston. Using phage display technology, the successful candidate will be responsible for the delivery of high-quality antibodies or binding proteins for therapeutic programs. They will apply automation methods for efficient selection and screening, as well as high-volume sequencing and data processing. They will analyze in vitro display output and will use recombinant DNA techniques to reformat screening output into the final therapeutic modality. The successful candidate will demonstrate understanding, flexibility, and efficiency in running multiple experiments in a collaborative environment. As a member of the In Vitro Display Group, the scientist would also contribute to the implementation of novel technologies for biologics discovery. Experience in DNA library design and library construction, NGS sample processing and data analysis, and familiarity with antibody databases is a plus for the job responsibilities in this role.

Primary Responsibilities:

  • Design and execute phage display campaigns.

  • Apply automation for screening with a focus on high-throughput ELISA

  • Bulk sequence analysis using appropriate software

  • Hands-on experience in cloning antibody gene fragments into expression vectors

  • Standard molecular biology techniques for phage and DNA manipulation

  • Expertise in handling large sequence data sets and sequence analysis software.

Required Qualifications:

  • BS or MS in biochemistry, biology, immunology, biotechnology, or a related discipline with relevant research experience

  • Hands-on experience in molecular biology and recombinant DNA techniques

Preferred Qualifications:

  • Excellent communication and collaboration skills

  • Antibody discovery and high throughput screening in an industrial setting

  • Background in automated liquid handling

  • Experience with the use of bioinformatic tools for sequence analysis

  • Experience with ELISA, Western blot, flow cytometry, cell culture

  • NGS sample preparation from display outputs and data analysis is a plus

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.


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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

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Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

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Requisition ID:R133043