Senior Scientist, Neuroscience (R133332)
The Neuroscience Department is seeking a highly motivated and skilled scientist with a strong desire to pursue drug discovery for neurodegenerative diseases. The successful candidate will serve as a hands-on experimentalist responsible for designing, executing, and overseeing studies to support our central nervous system drug discovery efforts with a focus on neurodegenerative disorders. The candidate will have an expertise working with in vivo and in vitro model systems of neurodegenerative disorders to understand biomarkers of disease and target-related mechanisms. The primary responsibilities include the design and execution of studies to profile in vivo and ex vivo models of neurodegenerative disease, biochemical and histological assays to understand biomarkers of disease, target engagement and the mechanism of action of targets, and work well as a part of a collaborative team. The role will also require the ability to independently keep up with relevant scientific literature, implement new technical expertise and assay development, and be an active participant in the scientific dialogue in project meetings and internal/external scientific meetings.
Educational and experience requirements:
Degree in Neuroscience, Biochemistry, Pharmacology, or related discipline:
Master’s degree and at least 2 years of relevant work experience or Bachelor’s degree and at least 4 years of relevant work experience.
Required skills and experience
Broad subject matter expertise in neuroscience, neurodegenerative disease, proteinopathy, or related discipline
Ability to conceive, design, execute, and communicate complex experiments in the field of neuroscience as evidenced by a proven publication and presentation record
Experience with histological techniques including immunohistochemistry, immunofluorescence, in situ hybridization, RNA Scope
Track record in microscopy and image acquisition and analysis
Experience with in vivo rodent assays including handling, dosing, models of neurodegenerative disease, behavioral assays of motor function, necropsy, and neuroanatomy.
Highly developed oral and written communication skills.
Preferred skills and experience:
Subject matter expertise in biology and pathophysiology of neurodegenerative diseases (e.g. Alzheimer’s Disease, Parkinson’s Disease, ALS)
Familiarity with digital pathology and imaging systems and software including Zeiss, Leica, and HALO software.
Proficiency with in vitro lab techniques including protein and/or mRNA extraction, measurement, and visualization
Experience with molecular biology and biochemical assays such as qPCR, Western blot, and ELISA etc.
We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.
Who we are …
We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.
What we look for …
In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.
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