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Job Details

Pfizer: One of the World's Premier Biopharmaceutical Companies

Principal Scientist, Biology (4836853_La_Jolla)





La Jolla, California, United States


Pfizer Oncology Research & Development (ORD) in La Jolla, California, is seeking an individual who would be passionate about using their expertise in cancer biology to make impactful contributions to developing the next generation of innovative cancer medicines. Creativity, perseverance and attention to detail are essential. Strongest consideration will be given to candidates with deep expertise in either one area: cancer cell signaling; senescence; transcriptional regulation; 3D tumor cell culture techniques (especially multicellular tumor spheroids) and/or single cell-based analysis methods. Demonstrated cancer relevance of the past research topic(s) is required and evidenced by at least two first-author publications in peer-reviewed journals.


  • Actively participate in the development and progression of our next generation of small-molecule therapeutic programs

  • Work in a highly dynamic and multi-disciplinary drug discovery environment that fosters innovation

  • Define mechanisms of drug induced cancer cell senescence; or investigate transcription regulatory tumor cell mechanisms

  • Develop and apply novel 3D and/or single cell-based cell culture and analysis techniques to drug development and questions of tumor cell biology (including cell cycle, senescence, cell death, metabolism)

  • Develop hypotheses, apply excellent technical ability at the bench and execute analysis

  • Effectively communicate findings at various cross-functional team meetings

  • Publish impactful papers and patents


Basic Qualifications

  • PhD in Cellular or Molecular Biology, Biochemistry, Genetics, or related field

  • >3 years of post-doctoral experience

  • At least two first author publications in peer-reviewed scientific journals across past cancer research activities

  • Demonstrated accomplishments in cancer cell signaling

  • Deep expertise in either one of the cell biological areas or technical fields outlined above, as evidenced by at least one first-author publication in that field

  • CRISPR based techniques for gene knockout or editing, or pooled CRISPR based screening approaches

  • Flow cytometry and cell sorting

  • Strong writing, presentation and communication skills

Preferred Qualifications

  • Cell surface proteomics

  • Background/expertise in glycobiology

  • Computational biology (e.g. R, Python)

  • Filed patent applications


Eligible for Relocation Package

Eligible for Employee Referral Bonus

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development